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. 2023 Nov 16;24(22):16412. doi: 10.3390/ijms242216412

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Mitochondrial CpG and GpC hypermethylation induce upregulation of mitophagy- and autophagy-related genes. Heatmap representation of differentially expressed genes related to (A) cholestasis, (B) mitophagy, and (C) autophagy in 3 different untreated cell lines, including a cell line overexpressing an inactive MCviPI DNMT named MCviPI mutant (Mutant) and the MCviPI cell line or MSssI cell line overexpressing the GpC DNMT MCviPI and CpG DNMT MSssI, respectively. (n = 3 biologically independent replicates).