Table 2.

Descriptive and bivariate analyses of lifestyle, systemic, immunogenetic, and microbial factors, and serum antibodies against periodontophatogens by CAL.

Independent Variables	Clinical Attachment Loss
	Mild CAL n = 223		Moderate CAL n = 253		Advanced CAL n = 188		Missing Data		p-Value
	F	%	F	%	F	%	F	%
LIFESTYLE
Smoking History
Negative	168	76	179	70.7	105	55.8	5	0.7	<0.0001
Current	31	14	44	17.4	55	29.3
Former	22	10	39	11.9	28	14.9
Current Smoking
Negative	190	85.2	209	82.6	133	70.7	5	0.9	<0.0001
Positive	31	14.8	44	17.4	55	29.3
Alcohol consumption
Not	195	88.2	220	88.3	168	89.1	9	1.3	NS
Occasional	20	9	21	8.4	15	8.1
Frequent	6	2.7	8	3.2	5	2.7
Stress (Cortisol) mean ± SD	13.31 ± 1.20		13.04 ± 0.75		13.49 ± 0.72		12	1.8	NS
SYSTEMIC FACTORS
BMI
Normal	132	59.2	131	51.6	104	55.6	3	0.4	<0.05
Overweight	81	36.3	85	33.5	64	34.2
Obesity	10	4.5	38	14.9	19	10.2
Glycemia
<120 mg/dL	191	85.6	204	83.9	157	83.5	10	1.4	NS
>120 mg/dL	32	14.3	39	16	31	16.4
IMMUNOGENETIC FACTORS
SNP IL-1b
C-C	147	66.8	162	66.2	135	73.4	16	2.3	<0.05
T-T	18	8.2	29	11.8	22	12.1
CT/TC	55	25	44	18	23	12.6
SNP IL-1a
CC	127	60.5	125	53.2	124	55.9	16	2.4	<0.05
T-T	21	10	45	19.1	51	23
CT/TC	58	27.6	57	24.2	43	19.3
MICROBIAL FACTORS
Plaque index
Low	124	56.4	70	28.6	25	13.5	0	0.0	<0.0001
Middle	65	29.6	95	38.7	51	27.6
High	31	14	80	32.7	109	58.9
P. gingivalis
Not	115	51.8	80	31.3	45	23.9	2	0.3	<0.0001
Yes	107	48.2	145	68.7	143	76.1
T. forsythia
Not	119	53.6	68	26.6	52	22.3	2	0.3	<0.0001
Yes	103	46.4	187	73.4	143	77.6
T. denticola
Not	160	71.3	158	62.9	106	56.3	2	0.3	<0.05
Yes	63	29.7	93	37.1	82	43.7
A. actinomycetemcomitans
Not	215	96.8	232	90.9	169	89.9	2	0.3	<0.05
Yes	7	3.3	22	9.1	22	10.1
SERUM ANTIBODIES
IgG1 P. gingivalis
Low	76	34.1	99	38.7	47	25	0	0.0	<0.10
Middle	61	27.3	92	35.9	69	36.7
High	86	38.6	75	25.4	62	38.3
IgG1 T. forsythia
Low	75	33.6	82	32.4	63	33.5	0	0.0	NS
Middle	65	29.1	80	31.6	73	38.8
High	83	37.3	91	36.0	52	27.7
IgG1 A. actinomycetemcomitans
Low	99	39.1	80	31.6	56	29.7	0	0.0	<0.10
Middle	84	33.2	81	32.1	64	34
High	70	27.6	92	36.3	68	36.3
IgG2 P. gingivalis
Low	91	41	81	31.7	50	26.6	0	0.0	<0.05
Middle	67	30.2	83	32.4	73	38.8
High	64	28.8	92	35.9	65	34.6
IgG2 T. forsythia
Low	88	39.4	84	33.2	51	27.1	0	0.0	NS
Middle	66	29.6	87	34.4	68	36.2
High	69	31.1	82	32.4	69	36.7
IgG2 A. actinomycetemcomitans
Low	92	41.4	84	32.8	46	24.5	0	0.0	<0.05
Middle	65	29.3	92	35.9	75	34.6
High	65	29.3	80	31.3	67	40.9