Table 1.

Summary of discussed tumor types, target proteins, and related employed TPD-based approaches.

Cancer Types	Target Protein	TPD Approach	References
Solid tumors
Prostate cancer	AR	ARCC-4 PROTAC	[30]
	AR Splice Variant-7	MTX-23 PROTAC	[61]
Breast cancer	Estrogen receptor	ARV-471 PROTAC	[62]
		AC682 PROTAC
		DT2216 PROTAC
	SGK3	SGK3-PROTAC1, HaloTag tool	[38,50]
	IGF-1R/Src	CPR3/CPR4 PROTACs	[63]
	BRD4	Ab-PROTAC 3	[64]
	BRD4	Bioorthogonal PROTAC	[65]
Lung cancer	IGF-1R/Src	CPR3/CPR4 PROTACs	[63]
	BRD4	H2O2-inducible PROTAC	[66]
	EML4-ALK fusion	dALK opto-PROTAC	[67]
Osteosarcoma	BET proteins	MZ1 PROTAC	[29]
		BETd-260 PROTAC	[68]
Ewing sarcoma	EWS::FLI1	dTAG tool	[43]
	TRIM8	dTAG tool	[69]
	ETV6	dTAG tool	[70]
	BRD4	BETd PROTAC	[71]
	CK1	CK1α PROTAC	[72]
Glioblastoma	HDAC6	J22352 PROTAC	[57]
Rhabdomyosarcoma	SMARCA4/A2	ACBI-1 PROTAC	[73]
	PAX3::FOXO1	dTAG tool	[74]
Melanoma	Mutant BRAF	SJF-0661 PROTAC	[53]
Synovial sarcoma	BRD9	dBRD9-A PROTAC	[75]
		CFT8634	[76]
		FHD-609	[76]
Cervical carcinoma	BET proteins	MZ1 PROTAC	[29]
Hematological tumors
Diffuse large B-cell lymphoma	BTK	UBX-382 PROTAC	[77]
Chronic myeloid leukemia	BCR-ABL1	DMP11 PROTAC	[78]
		GMB-475 PROTAC	[79]
	LIN28	RNA-PROTAC	[80]
	STAT5	AK-2292 PROTAC	[81]
MLL-rearranged leukemia	IKZF	MS40 PROTAC	[82]
Acute myeloid leukemia	CDK2/CDK5	dTAG tool	[43]
Anaplastic large cell lymphoma	NPM-ALK fusion	dALK opto-PROTAC	[67]