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Concentration-dependent effect of huperzine A (Hup A) on amplitude (A) and decay time constant (B) of miniature end-plate potentials (MEPP) recorded in mouse diaphragm muscle. CTR—control (intact AChE) values. The inset shows representative MEPPs recorded in the control (left MEPP) and after application of 100 nM huperzine A (right MEPP). Mean ± SEM obtained from 20 NMJs, 100 MEPPs in each NMJ were analyzed.
