Table 2.

Cox proportional hazards regression model results for the rs16844448 × beta-blocker exposure interaction term in black patients in HFGR and HF-ACTION.

	HFGR (n = 469)				HF-ACTION (n = 288)
Variable	Coeff.	HR	95% CI	p-Value	Coeff.	HR	95% CI	p-Value
rs16844448 × beta-blocker exposure interaction	4.3	73.7	15.4–353.5	8.1 × 10−6	4.0	55.1	3.4–865.8	0.005
MAGGIC (excluding beta-blocker)	0.1	1.1	1–1.2	<0.001	0.1	1.1	1–1.2	<0.001
Beta-blocker propensity score	0.05	1.0	0.9–1.2	0.600	0.04	1.0	0.8–1.4	0.800

CI—confidence interval; Coeff.—coefficient; HF-ACTION—Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training [17]; HFGR—Heart failure pharmacogenomic registry [9]; HR—hazard ratio; MAGGIC—Meta-Analysis Global Group in Chronic Heart Failure risk score [21].