Table 1.
Laboratory, systemic and renal function parameters measured in nondiabetic and diabetic mice at 18 weeks of age.
| Groups | Body Weight | Blood Glucose | SBP | GFR | uACR |
|---|---|---|---|---|---|
| (g) | (mg/dL) | (mmHg) | (μL/min) | (μg/mg) | |
| BTBR WT | 39 ± 2 | 130 ± 7 | 101 ± 2 | 202 ± 39 | 32 ± 3 |
| (n = 6) | (n = 6) | (n = 6) | (n = 5) | (n = 6) | |
| BTBR ob/ob | |||||
| vehicle | 49 ± 2 * | 554 ± 20 ** | 96 ± 4 | 612 ± 73 * | 861 ± 210 ** |
| (n = 7) | (n = 7) | (n = 7) | (n = 6) | (n = 7) | |
| ACEi | 49 ± 2 | 576 ± 16 | 83 ±4° | 505 ±95 | 307 ± 65 ° |
| (n = 7) | (n = 7) | (n = 7) | (n = 6) | (n = 7) |
Data are mean ± SEM. * p < 0.01, ** p < 0.0001 vs. BTBR WT; ° p < 0.05 vs. BTBR ob/ob + vehicle (one-way ANOVA with Tukey’s post hoc test). ACEi, angiotensin-converting enzyme inhibitor; SBP, systolic blood pressure; GFR, glomerular filtration rate; uACR, urinary albumin-to-creatinine ratio.