The systemic changes caused by burns that exceed 30% of TBSA. Abbreviations: glomerular filtration rate (GFR), systemic vascular resistance (SVR), systemic inflammatory response syndrome (SIRS), thyroid stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), insulin-like growth factor binding protein-3 (IGFBP-3), transforming growth factor-β (TGF-β), insulin-like growth factor (IGF), insulin-like growth factor 1 (IGF-1), vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF), growth hormone (GH), interleukin 1, 6, 8, 18 (IL-1, -6, -8, -18), and total body surface area (TBSA).