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Mechanism of action for cannabinoids in pruritis. CB1R/CB2R agonist ameliorated chronic itching by suppressing Il-13 and IL-31. CB1R knockout in sensory neurons promoted the production of substance P, which induces the accumulation of mast cells in the dermis through ERK. CBD: cannabidiol; ERK: extracellular signal-regulated kinase. This figure was created with Biorender at www.biorender.com (accessed on 21 August 2023).
