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. 2023 Nov 20;24(22):16523. doi: 10.3390/ijms242216523

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Mechanism of action of cannabinoids in psoriasis CBD inhibited TNF-α-induced NF-κB transcription, which plays important role in psoriasis, and keratinocyte proliferation through PPAR-γ. CB2R deficiency inhibited the differentiation of CD4 T cells through STAT5/ROR γ T. Human mesenchymal stem cells express all of the components of endocannabinoid system, including CB1R/CB2R. And CB2R stimulation reduced pro-inflammatory cytokines in mesenchymal stem cells. MMP: matrix metallopeptidase; Th17: T-helper 17 cell; TNF-α: tumor necrosis factor; CBD: cannabidiol; THC: Δ-9-tetrahydrocannabinol; TRPV: transient receptor potential vanilloid; NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells; PPAR-γ: peroxisome proliferator-activated receptor; ROR: AR-related orphan nuclear receptor. This figure was created with Biorender at www.biorender.com (accessed on 21 August 2023).