Table 1.
Principal studies reporting data about HBP-CRT.
| Study | Design | Patients’ Allocation | BBB Correction Rate | HBP Threshold at Implant (V) * | HBP Threshold at Follow-Up (V) * | Mean Follow-Up (Months) | Outcomes # | HBP Lead Related Complications (%) # |
|---|---|---|---|---|---|---|---|---|
| Barba et al. [56] Europace, 2013 | observational, retrospective, single-centre |
HBP: 16 | 81% temporarily 56% permanently |
3.1 ± 0.4 | 3.7 ± 0.5 | 31 | QRS narrowing, LVEF improvement and reduction in LVEDD and LVESD | 0 |
| Lutsgarten et al. [57] Heart Rhythm, 2015 | randomized, crossover, multicentre | HBP: 29 BiVP: 29 |
72% | 1.3 ± 2.2 | 2.4 ± 4.5 | 12 | LVEF, NYHA class, 6MWT and QoL significantly improved with both HBP and BiVP | 10.3 |
| Sharma et al. [58] Heart Rhythm, 2018 | observational, retrospective, multicentre |
HBP: 106 | 90% | 1.4 ± 0.9 | 2.0 ± 1.2 | 14 | QRS narrowing, LVEF and NYHA class improvement | 6.6 |
| Huang et al. [59] Heart, 2019 | observational, prospective, single-centre | HBP: 74 | 97% temporarily 76% permanently |
1.9 ± 1.1 | 2.3 ± 0.9 | 37 | QRS narrowing, LVEF and NYHA class improvement | 0 |
| Moriña-Vázquez et al. [60] Europace, 2020 | observational, prospective, single-centre |
HBP: 48 | 81% | 1.6 (0.9–1.9) | 0.9 (0.7–2) | 6 | QRS narrowing, LVEF and dyssynchrony parameters improvement | 0 |
| Upadhyay et al. [61] Heart Rhythm, 2019 | randomized, prospective, multicentre | HBP: 21 BiVP: 20 |
52% | 2.75 (1.3–3.4) | 2 (1–3.3) | 12 | QRS narrowing, trend towards higher echo response with HBP vs. BiVP | 0 |
| Vinther et al. [62] JACC EP, 2021 | randomized, prospective, single-centre | HBP: 25 BiVP: 25 |
72% | 2.2 ± 1.2 | 2.4 ± 1.6 | 6 | LVEF significantly higher and LVESV significantly lower in HBP group at 6 months | 5.3 |
| Huang et al. [63] Heart Rhythm, 2022 |
randomized, prospective, multicentre, crossover |
HBP: 50 BiVP: 50 |
N/A, patients with baseline narrow QRS undergoing AV node ablation | 0.9 ± 0.6 | 0.9 ± 0.6 | 9 | significant improvement in LVEF with HBP vs. BiVP | 0 |
| Whinnet et al. [64] Eur J Heart Fail, 2023 | randomized, crossover, multicentre | HBP: 167 | 93% | N/A | N/A | 6 | HBP did not increased peak O2 uptake but significantly improved QoL | 5.6 |
* HBP threshold refers to the BBB correction threshold. Note that HB pacing thresholds were measured at different pulse widths depending on the study. # In randomized studies, outcomes and HBP lead-related complications are reported as per-protocol analyses. BBB: Bundle branch block; BiVP: Biventricular pacing; HBP: His bundle pacing; LVEDD: Left ventricular end-diastolic diameter; LVEF: Left ventricular ejection fraction; LVESD: Left ventricular end-systolic diameter; LVESV: Left ventricular end-systolic volume; NYHA: New York Heart Association; QoL: Quality of life; 6MWT: 6-min walking test.