Table 3.
Multivariate Cox analysis of metastatic overall survival.
| Variable | HR | 95.0% CI for HR | p |
|---|---|---|---|
| Median age (reference: median age less than the median) |
1.785 | 0.962–3.313 | 0.06 |
| Sex (reference: male sex) |
1.651 | 0.883–3.089 | 0.11 |
| ECOG PS (reference: ECOG PS 0–1 group) |
0.051 | 0.009–0.292 | 0.001 |
| Surgery for primary tumor (reference: no surgery) |
3.812 | 1.584–9.174 | 0.003 |
| PFS1 (reference: PFS1 less than the median) |
0.571 | 0.228–1.430 | 0.23 |
| Best Response to 1-line CT (reference: disease control) |
0.203 | 0.073–0.560 | 0.002 |
| 2-line CT G vs. FU (reference: 2-line CT G) |
1.008 | 0.463–2.190 | 0.98 |
| PFS2 (reference: PFS2 less than the median) |
3.494 | 1.679–7.269 | 0.001 |
CT = chemotherapy; pts = patients; PFS1 = progression-free survival for first-line chemotherapy; PFS2 = progression-free survival for second-line chemotherapy; G = gemcitabine; FU = fluoropyrimidine; HR = hazard ratio.