Table 2.

Summary of fibrate effects on KYNA formation and KAT activity in rat kidneys in vitro. Data shown as a percentage of control KYNA synthesis. Fenofibrate and gemfibrozil concentrations that did not show any effect on KYNA production or KAT activity (0.001 mM, 0.01 mM and 0.05 mM) are not presented. NS, non-significant. * p < 0.05; ** p < 0.01, *** p < 0.001 vs. control (ANOVA).

	Fenofibrate (mM)			Gemfibrozil (mM)
	0.1 mM	0.5 mM	1 mM	0.1 mM	0.5 mM	1 mM
KYNA production	72% *	60% ***	51% ***	66% ***	58% ***	41% ***
KAT I activity	NS	68% *	59% *	68% *	56% **	52% **
KAT II activity	78% *	63% **	64% *	NS	47% ***	26% ***