Table 3.
Logistic regression analysis for prognostic factors for disease progression in patients with IPF (Total patients).
| Variable | Unadjusted Analysis | Multivariable Analysis | ||
|---|---|---|---|---|
| OR (95% CI) | p-Value | OR (95% CI) | p-Value | |
| Age | 0.97 (0.88–1.06) | 0.472 | ||
| Male | 0.12 (0.02–0.70) | 0.018 | 0.12 (0.02–0.70) | 0.018 |
| Smoking | 0.34 (0.06–1.82) | 0.207 | ||
| BMI | 0.78 (0.60–1.02) | 0.065 | ||
| Pulmonary function | ||||
| FVC, % predicted | 0.98 (0.93–1.02) | 0.326 | ||
| DLco, % predicted | 0.98 (0.93–1.03) | 0.478 | ||
| Six-minute walk test | ||||
| Distance | 0.99 (0.99–1.00) | 0.189 | ||
| Lowest SpO2 | 0.95 (0.83–1.09) | 0.453 | ||
| Baseline KL-6 | 1.00 (1.00–1.00) | 0.496 | ||
| Δ KL-6, % * | 1.03 (1.00–1.06) | 0.077 | ||
* The relative change in KL-6 value from baseline to 12 months. IPF, idiopathic pulmonary fibrosis; OR, odds ratio; CI, confidence interval; BMI, body mass index; FVC, forced vital capacity; DLco, diffusing capacity of the lung for carbon monoxide; SpO2, percutaneous oxygen saturation; KL-6, Krebs von den Lungen-6.