Table 4.
Logistic regression analysis for prognostic factors for disease progression in IPF patients with high baseline KL-6 levels (≥500 U/mL).
| Variable | Unadjusted Analysis | Multivariable Analysis | ||
|---|---|---|---|---|
| OR (95% CI) | p-Value | OR (95% CI) | p-Value | |
| Age | 0.97 (0.84–1.11) | 0.644 | ||
| Male | 0.17 (0.03–1.14) | 0.069 | 0.09 (0.01–0.63) | 0.015 |
| Smoking | 0.38 (0.05–2.78) | 0.342 | ||
| BMI | 0.59 (0.36–0.96) | 0.034 | ||
| Pulmonary function | ||||
| FVC, % predicted | 0.98 (0.92–1.03) | 0.434 | ||
| DLco, % predicted | 0.98 (0.92–1.04) | 0.573 | ||
| Six-minute walk test | ||||
| Distance | 1.00 (0.99–1.01) | 0.548 | ||
| Lowest SpO2 | 0.97 (0.83–1.12) | 0.645 | ||
| Baseline KL-6 | 1.00 (1.00–1.00) | 0.749 | ||
| Δ KL-6, % * | 1.04 (1.00–1.08) | 0.043 | 1.03 (1.00–1.06) | 0.074 |
* The relative change in KL-6 value from baseline to 12 months. IPF, idiopathic pulmonary fibrosis; KL-6, Krebs von den Lungen-6; OR, odds ratio; CI, confidence interval; BMI, body mass index; FVC, forced vital capacity; DLco, diffusing capacity of the lung for carbon monoxide; SpO2, percutaneous oxygen saturation.