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. 2023 Oct 30;13(11):1560. doi: 10.3390/jpm13111560

Table 2.

Operating characteristics of the design.

Prevalence of
Positive x2 		Average
Sample Size		 False/True
Positive Rate		 Early
Stopping Rate
Scenario 1:
No prognostic and
predictive value of
biomarker		 0.2 1754 0.066 0.035
0.4 1738 0.082 0.048
0.5 1728 0.088 0.055
0.6 1734 0.096 0.051
0.8 1730 0.087 0.054
Scenario 2:
Only prognostic
value of
biomarker x1 		0.2 1692 0.212 0.083
0.4 1687 0.206 0.087
0.5 1686 0.204 0.088
0.6 1676 0.206 0.095
0.8 1690 0.183 0.085
Scenario 3:
Only predictive
value of
biomarker x2 		0.2 1579 0.437 0.172
0.4 1384 0.693 0.328
0.5 1176 0.862 0.485
0.6 1072 0.989 0.561
0.8 734 0.999 0.824
Scenario 4:
Prognostic value of both
and quantitative
interaction with x1 and x2 		0.2 1237 0.888 0.433
0.4 932 0.994 0.668
0.5 774 0.998 0.789
0.6 669 0.999 0.870
0.8 551 1.000 0.961
Scenario 5:
Qualitative and
quantitative interaction
in both biomarker		 0.2 1799 0.001 0.001
0.4 1800 0.000 0.000
0.5 1800 0.000 0.000
0.6 1800 0.000 0.000
0.8 1799 0.001 0.001
Scenario 6:
Qualitative and
quantitative interaction
in both biomarker II		 0.2 1786 0.015 0.011
0.4 1771 0.047 0.022
0.5 1738 0.088 0.048
0.6 1701 0.147 0.076
0.8 1622 0.334 0.137