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. 2023 Nov 15;59(11):2008. doi: 10.3390/medicina59112008

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Reproduction of Figure 2 from Bouchard et al. 2018 [1] showing ovarian quiescence with delayed ovulation (mucus/bleeding colours—green: dry; yellow: non-lubricative sticky mucus; blue: lubricative, clear, stretchy mucus; red: bleeding/menstruation; TE: total urinary estrogens; end of full breastfeeding with introduction of solids indicated by arrow at 4.5 months, and complete weaning indicated by arrow at 11 months). Mira Analyzer data in (B,C) show very low estrogenic activity with LH rises (marked levels) that did not lead to ovulation. In (C), a high LH surge of 66 was required to trigger ovulation, confirmed with a PDG rise (marked) and the first menses, leading to the first menstrual cycle in (D).