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Enzyme kinetics and the protein–ligand docking study. (a) Measured KM and Ki values of quercetin analogs against VIM-2 with its colorimetric substrate, nitrocefin. (b) Predicted binding mode of compound #5 with the VIM-2 (PDB: 4C1D) enzyme. (c) Docking score comparison between compound #1a (quercetin) and #5 (taxifolin). (d) Predicted bond distance between compound #5 and Zn(1) and Zn(2) at the active site of the VIM-2 enzyme. ** indicates p < 0.01.
