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The ability of tiamulin (2) (left) and polyamine conjugate 9e (right) to act as membrane disruptors in P. aeruginosa PAO1, as determined using a nitrocefin hydrolysis assay. Polymixin B (PMB) was the positive control (98.3 μM, 128 μg/mL), and the negative control was bacteria with nitrocefin.
