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Chemistry route for probe synthesis. Reagent and conditions: i) hydroxylamine-O-sulfonic acid (HOSA), KHCO3, H2O, 80 °C, 14 h; ii) ethynyltrimethyl silane, Pd(dppf)Cl2 · CH2Cl2, CuI, PPh3, TEA, THF, 70 °C, 15 min; iii) KHCO3, KOH, H2O, DCM, r.t, 18 h; iv) 3-methoxy-5-(trifluoromethyl)aniline, TFA, tert-BuOH, 85 °C, 15 h.
