Fig. 4.

NIR-PIT induces immunogenic tumor cell death and increases Ti-DC migration from tumor to dLN via ATP-P2X7R and Gαi-protein-coupled receptor signaling pathways. cDC1s, cDC2s, CD326⁺ DCs, and MoDCs migrate from tumor to dLNs. When ICD was induced by NIR-PIT, DAMPS molecules such as P2X7 released from dying tumor cells stimulate maturation and increase cDC1s, cDC2s, CD326⁺ DCs migration. NIR-PIT enhanced migration of Ti-DCs including cDC1s, cDC2s, and CD326⁺ DCs to dLNs via Gαi protein-coupled receptor signaling pathways