Table 3.

Inter-rater reliability of the GS, RHI, NI and component scores at Week 52 [Inter-AP1^a: N = 151]

Score	ICCb [95% CI]
GSc	0.530a [0.496, 0.563]
RHI scored	0.905b [0.875, 0.928]
NI scoree	0.640a [0.605, 0.675]
GS Grade 0: Structuralf	0.468a [0.427, 0.509]
GS Grade 1: Chronic inflammatory infiltratef	0.579a [0.539, 0.619]
GS Grade 2A: Eosinophils in lamina propriaf	0.270a [0.214, 0.325]
GS Grade 2B: Neutrophils in lamina propriaf	0.552a [0.512, 0.591]
GS Grade 4: Crypt destructionf	0.425a [0.381, 0.469]
GS Grade 5: Erosion or ulcerationf	0.522a [0.483, 0.561]
GS severity scoreg	0.647a [0.600, 0.693]

CI, confidence interval; GS, Geboes score; ICC, intraclass correlation coefficient; inter-API, inter-rater reliability analysis population; NI, Nancy Index; RHI, Robarts Histopathology Index.

Note: Inter-AP1 are patients from the M14-033 trial with ratings by multiple physicians on the GS, RHI or NI at Week 52.

^aOnly Inter-AP patients with scores rated by at least two physicians were included in the analysis.

^bThe ICC was computed using the [a]weighted Kappa or [b]single measurement absolute agreement two-way mixed effects model.

^cThe GS is an ordinal score that ranges from 0 to 5, with higher scores associated with greater levels of inflammation.

^dThe RHI score ranges from 0 to 33, with higher scores associated with more severe disease activity.

^eThe NI score is an ordinal score that ranges from 0 to 4, with higher scores associated with greater disease severity.

^fThe GS components are from the rectum or sigmoid tissue sample associated with the highest GS at the visit.

^gThe GS severity score is an ordinal score that ranges from 1 to 3, with higher scores associated with greater levels of severity.