Table 2.
Utility and costs over the study period for both randomization groups and the difference with the 95% bootstrapped bias-corrected accelerated [BCa] confidence intervals [CI].
| Control | Intervention | Difference | |||||
|---|---|---|---|---|---|---|---|
| Observed1 | Bootstrapped1 | Observed1 | Bootstrapped1 | Observed2 | Bootstrapped2 | 95% BCa CI3 | |
| Quality of life | |||||||
| QALYs | 0.851 [0.049] | 0.851 [0.058] | 0.833 [0.093] | 0.833 [0.096] | −0.018 | −0.017 | [−0.044; 0.004] |
| Costs | |||||||
| Total societal costs | €10 822 [€3755] | €11 827 [€4069] | €9991 [€6961] | €10 883 [€7040] | −€831 | −€943 | [−€2226; €1367] |
| Healthcare | |||||||
| Total healthcare costs | €9295 [€1093] | €9541 [€1136] | €7251 [€2063] | €7469 [€2129] | −€2044 | −€2071 | [−€2524; −€1471] |
| Total medication costs | €7592 [€598] | €7642 [€682] | €5060 [€1012] | €5098 [€1060] | −€2532 | −€2545 | [−€2780; −€2192] |
| Adalimumab | €7502 [€515] | €7525 [€602] | €4784 [€621] | €4803 [€683] | −€2717 | −€2723 | [−€2898; −€2406] |
| Other medication | €90 [€261] | €117 [€315] | €276 [€831] | €295 [€806] | €186 | €178 | [€58; €464] |
| Total non-medication healthcare costs | €1703 [€825] | €1898 [€902] | €2190 [€1507] | €2372 [€1551] | €488 | €474 | [€149; €952] |
| Out-of-hospital care | €235 [€269] | €305 [€345] | €496 [€895] | €576 [€925] | €261 | €272 | [€56; €524] |
| Gastroenterology visits | €956 [€313] | €969 [€324] | €1046 [€312] | €1054 [€317] | €90 | €85 | [−€7; €193] |
| Admissions | €86 [€271] | €131 [€354] | €150 [€488] | €192 [€538] | €65 | €61 | [−€56; €243] |
| Diagnostics | €289 [€200] | €307 [€214] | €337 [€321] | €346 [€317] | €48 | €40 | [−€21; €141] |
| ER visits | €21 [€75] | €35 [€107] | €55 [€177] | €68 [€191] | €35 | €33 | [−€5; €91] |
| Other specialist visits | €117 [€215] | €152 [€225] | €106 [€199] | €136 [€208] | −€11 | −€16 | [−€95; €57] |
| Productivity | |||||||
| Total productivity losses | €1499 [€3088] | €2166 [€3431] | €2329 [€4796] | €2929 [€4998] | €830 | €763 | [−€327; €2284] |
| Absenteeism | €652 [€1712] | €916 [€1957] | €837 [€2322] | €1080 [€2504] | €185 | €164 | [−€504; €941] |
| Presenteeism | €506 [€1597] | €737 [€1670] | €837 [€1933] | €1043 [€2042] | €331 | €306 | [−€350; €864] |
| Unpaid work | €341 [€1518] | €513 [€1662] | €655 [€2869] | €806 [€2767] | €314 | €293 | [−€310; €1274] |
| Patient | |||||||
| Informal care | €28 [€187] | €120 [€589] | €411 [€2079] | €485 [€2032] | €383 | €365 | [€92; €1,058] |