Table 3.
Linear regression analysis of factors associated with total fatigue score as the dependent variable.
| Ulcerative colitis | ||||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | |||||||
| Factors | Unst. B | 95% CI | Effect size | p-value | Unst. B | 95% CI | Effect size | p-value |
| Sex [ref. male] | −2.32 | [−3.11, −1.52] | −0.22 | <0.001 | −0.89 | [−2.11, 0.32] | −0.09 | n.s. |
| Age, years | −0.02 | [−0.05, 0.004] | −0.07 | <0.1 | 0.02 | [−0.03, 0.06] | 0.04 | n.s. |
| Comorbidities | 1.08 | [0.71, 1.45] | 0.22 | <0.001 | −0.57 | [−1.13, −0.08] | −0.11 | <0.05 |
| HADS-D | 0.82 | [0.72, 0.92] | 0.55 | <0.001 | 0.64 | [0.48, 0.80] | 0.46 | <0.001 |
| HADS-A | 0.58 | [0.49, 0.67] | 0.45 | <0.001 | - | - | - | - |
| PSQI | 0.68 | [0.52, 0.84] | 0.47 | <0.001 | 0.28 | [0.11, 0.46] | 0.20 | <0.01 |
| BPI [pain intensity] | 0.36 | [0.27, 0.44] | 0.45 | <0.001 | 0.15 | [0.05, 0.25] | 0.18 | <0.01 |
| SCCAI | 0.60 | [0.47, 0.73] | 0.33 | <0.001 | 0.38 | [0.18, 0.58] | 0.22 | <0.001 |
| Haemoglobin [g/dL] | −0.62 | [−0.86, −0.39] | −0.20 | <0.001 | −0.11 | [−0.50, 0.29] | −0.03 | n.s. |
| Calprotectin >250 µg/g | 0.73 | [−0.16, 1.59] | 0.07 | n.s. | ||||
| CRP ≥5 mg/L | 1.13 | [0.20, 2.05] | 0.10 | <0.05 | −1.62 | [−3.1, −0.13] | −0.13 | <0.05 |
| Albumin [g/L] | −0.15 | [−0.20, −0.07] | −0.15 | <0.001 | −0.01 | [−0.17, 0.15] | −0.01 | n.s. |
| Mayo endoscopic score | 0.93 | [0.32, 1.54] | 0.12 | <0.01 | 1.32 | [0.35, 2.30] | 0.15 | <0.01 |
| Factors | Crohn’s disease | |||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | |||||||
| Unst. B | 95% CI | Effect size | p-value | Unst. B | 95% CI | Effect size | p-value | |
| Sex [ref. male] | −3.17 | [−4.35, −1.98] | −0.29 | <0.001 | −0.54 | [−2.45, 1.36] | −0.05 | n.s. |
| Age, years | −0.05 | [−0.09, −0.01] | −0.14 | <0.05 | −0.07 | [−0.12, −0.02] | −0.19 | <0.01 |
| Comorbidities | 1.12 | [0.60, 1.64] | 0.23 | <0.001 | 0.37 | [−0.46, 1.20] | 0.07 | n.s. |
| HADS-D | 0.75 | [0.60, 0.89] | 0.51 | <0.001 | 0.61 | [0.36, 0.87] | 0.38 | <0.001 |
| HADS-A | 0.57 | [0.43, 0.70] | 0.44 | <0.001 | - | - | - | - |
| PSQI | 0.78 | [0.55, 1.01] | 0.51 | <0.001 | 0.47 | [0.17, 0.72] | 0.29 | <0.05 |
| BPI [pain intensity] | 0.34 | [0.23, 0.45] | 0.46 | <0.001 | 0.17 | [0.03, 0.31] | 0.22 | <0.05 |
| HBI | 0.47 | [0.30, 0.64] | 0.30 | <0.001 | −0.05 | [−0.29, 0.20] | −0.03 | n.s. |
| Haemoglobin [g/dL] | −0.60 | [−1.03, −1.18] | −0.16 | <0.01 | −0.27 | [−0.92, 0.39] | −0.06 | n.s. |
| Calprotectin >250 µg/g | 0.39 | [−0.92, 1.69] | 0.04 | n.s. | ||||
| CRP ≥5 mg/L | 0.31 | [−0.96, 1.57] | 0.03 | n.s. | ||||
| Albumin [g/L] | 0.01 | [−0.03, 0.22] | 0.09 | n.s. | ||||
| Colon affected [L2] | 1.68 | [0.03, 3.34] | 0.11 | <0.05 | −0.03 | [−2.46, 2.40] | −0.002 | n.s. |
| Modified SES-CD | 0.03 | [−0.26, 0.33] | 0.01 | <0.1 | 0.008 | [−0.41, 0.43] | 0.003 | n.s. |
CI: confidence interval, Unst. B: unstandardized B, n.s.: not significant, HADS: Hospital Anxiety and Depression Scale [D = Depression, A = Anxiety], PSQI: Pittsburg Sleep Quality Index, BPI: The Brief Pain Inventory, HBI: Harvey–Bradshaw index, SCCAI: Simple Clinical Colitis Activity Index, CRP: C-reactive protein, L2: CD localization, Montreal classification. Effect size: small effect = 0.02, medium effect = 0.15, large effect = 0.35.