Table 4.
Binary logistic regression analysis of factors associated with substantial fatigue as the dependent variable.
| Factors | Ulcerative colitis | |||
|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | |||
| OR [95% CI] | p-value | OR [95% CI] | p-value | |
| Sex [ref. male] | 0.38 [0.28, 0.562] | <0.001 | 0.58 [0.25, 1.33] | n.s. |
| HADS-D ≥ 8 | 12.04 [5.49, 26.40] | <0.001 | 16.79 [2.03, 139.25] | <0.01 |
| HADS-A ≥ 8 | 5.49 [3.59, 8.41] | <0.001 | ||
| PSQI > 5 | 6.20 [3.46, 11.10] | <0.001 | 4.60 [1.86, 11.40] | <0.001 |
| BPI [pain intensity] | 1.13 [1.07, 1.18] | <0.001 | 1.04 [0.97, 1.12] | n.s. |
| SCCAI ≥ 3 | 2.65 [1.91, 3.68] | <0.001 | 3.51 [1.52, 8.13] | <0.01 |
| Anaemiaa | 1.21 [0.77, 1.92] | n.s. | ||
| Calprotectin >250 µg/g | 1.42 [1.01, 1.99] | <0.05 | 1.16 [0.49, 2.72] | n.s. |
| CRP ≥ 5 mg/L | 1.61 [1.11, 2.31] | <0.05 | 0.62 [0.23, 1.67] | n.s. |
| Mayo endoscopic score ≥2 | 1.42 [0.98, 2.05] | <0.1 | 1.70 [0.54, 5.41] | n.s. |
| Crohn’s disease | ||||
|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | |||
| Factors | OR [95% CI] | p-value | OR [95% CI] | p-value |
| Sex [ref. male] | 0.34 [0.29, 0.55] | <0.001 | 0.74 [0.22, 2.52] | n.s. |
| HADS-D ≥ 8 | 12.72 [3.87, 41.75] | <0.001 | - | |
| HADS-A ≥ 8 | 3.92 [2.14, 7.18] | <0.001 | ||
| PSQI > 5 | 5.85 [2.45, 13.98] | <0.001 | 4.75 [1.32, 17.13] | <0.05 |
| BPI [pain intensity] | 1.20 [1.11, 1.30] | <0.001 | 1.28 [1.11, 1.47] | <0.001 |
| HBI ≥ 5 | 2.64 [1.52, 4.57] | <0.001 | 0.29 [0.07, 1.20] | n.s. |
| Anaemiaa | 0.96 [0.49, 1.87] | n.s. | ||
| Calprotectin > 250 µg/g | 1.21 [0.71, 2.07] | n.s. | ||
| CRP ≥ 5 mg/L | 1.12 [0.68, 1.84] | n.s. | ||
| Colon affected [L2] | 1.91 [0.91, 4.0] | <0.1 | 1.69 [0.33, 8.64] | n.s. |
OR: odds ratio, CI: confidence interval, n.s.: not significant, HADS: Hospital Anxiety and Depression Scale [D = Depression, A = Anxiety], PSQI: Pittsburg Sleep Quality Index, BPI: The Brief Pain Inventory, HBI: Harvey–Bradshaw index, SCCAI: Simple Clinical Colitis Activity Index, CRP: C-reactive protein, L2: CD localization, Montreal classification.
aHaemoglobin <13 [males] and <12 [females].