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. 2023 Nov 24;9:423. doi: 10.1038/s41420-023-01718-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — In colorectal cancer, miR-184 can act as a tumor suppressor by directly targeting IGF-1R. In gastric cancer, miR-184 inhibits STC2, thereby suppressing cell proliferation, invasion, and metastasis. However, there is controversy surrounding the role of circ_0021087, which has been reported to exert a tumor suppressor function in gastric cancer by targeting miR-184 and upregulating FOSB. In hepatocellular carcinoma, miR-184 targets INPPL1 and caspase 3/7, leading to the inhibition of cellular proliferation and promotion of apoptosis, respectively. Additionally, miR-184 inhibits C-Myc, C-Jun, and Bcl-2, contributing to the suppression of cell growth and apoptosis induction in pancreatic adenocarcinoma. STC2 stanniocalcin 2, IGF-1R insulin-like growth factor 1 receptor, INPPL1 inositol polyphosphate phosphatase-like 1.