Table 2.
Changes in clinical characteristics and echocardiographic parameters between the intervention group (n = 25) and the control group (n = 22) from baseline to follow-up. Difference in changes is calculated as change in the intervention group relative to the control group
| Intervention (Follow-up) |
Change from baseline | Control (Follow-up) |
Change from baseline | Diff. in changes from baseline | P-Value | |
|---|---|---|---|---|---|---|
| P-K, mmol/l | 4.51 (± 0.36) | 0.59 (± 0.34) | 4.05 (± 0.17) | 0.068 (± 0.25) | 0.52 (0.35; 0.69) | < 0.001* |
| Systolic bp, mmHg | 123 (± 11.2) | -3.92 (± 14.4) | 129 (± 14.9) | -3.68 (± 10.6) | -0.3 (-7.6; 7.2) | 0.95 |
| Diastolic bp, mmHg | 78.2 (± 9.3) | -2.2 (± 12.3) | 79.9 (± 10.3) | -1.82 (± 12) | -0.4 (-7.5; 6.8) | 0.91 |
| HR, (bpm) | 63.3 (± 8.9) | 0.85 (± 7.22) | 61.3 (± 10.9) | 0.061 (± 5.94) | 0.8 (-3.1; 4.7) | 0.68 |
| Systolic function | ||||||
| GLS, % | -15.8 (± 3.5) | -1.1 (± 1.39) | -14.6 (± 3.3) | -0.068 (± 1.94) | -1.0 (-2.0; -0.02) | < 0.05* |
| LVEF, % | 49 (± 7.17) | 0.28 (± 3.55) | 46.3 (± 8.21) | -1.23 (± 5.52) | 1.5 (-1.3; 4.3) | 0.28 |
| MD, ms | 48.7 (± 19.7) | -3.55 (± 11.9) | 60.8 (± 18.4) | 0.146 (± 15) | -3.7 (-11.8; 4.36) | 0.36 |
| TAPSE, cm | 2.11 (± 0.36) | -0.072 (± 0.35) | 1.98 (± 0.53) | -0.15 (± 0.35) | 0.07 (-0.13; 0.28) | 0.29 |
| RV FWS, % | -24.5 (± 5.77) | -0.88 (± 4.36) | -22.4 (± 5.22) | -0.76 (± 3.31) | -0.12 (-2.58; 2.34) | 0.92 |
| Diastolic function | ||||||
| E, cm/s | 56.6 (± 24.5) | -4.48 (± 10.4) | 60.5 (± 23.6) | -1.41 (± 9.42) | -3.07 (-8.89; 2.75) | 0.29 |
| A, cm/s | 50.1 (± 15.3) | -3.43 (± 13.6) | 49.4 (± 11.9) | -1.7 (± 4.35) | -1.73 (-7.89; 4.43) | 0.57 |
| E/A | 1.2 (± 0.734) | -0.0013 (± 0.21) | 1.25 (± 0.59) | 0.040 (± 0.24) | -0.041 (-0.18; 0.10) | 0.56 |
| e’, cm/s | 7.68 (± 2.69) | 0.58 (± 1.44) | 7.25 (± 2.36) | -0.27 (± 1.39) | 0.85 (0.02; 1.68) | 0.04* |
| E/e’ | 7.97 (± 2.85) | -1.52 (± 2.81) | 9.03 (± 3.87) | 0.023 (± 1.89) | -1.54 (-2.94; -0.14) | 0.03* |
P-value for difference in mean change in the intervention group and the control group
Displayed as mean (± SD) or number (%). A: Late diastolic mitral inflow velocity, E: early diastolic mitral inflow velocity, e’: Early diastolic
mitral annular velocity, HR: Heart rate, LVEF: Left ventricular ejection fraction, GLS: Global Longitudinal Strain, MD: Mechanical dispersion, RV FWS: Right ventricular free wall strain, TAPSE: Tricuspid annular plane systolic excursion