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. 2023 Nov 24;71(1):24. doi: 10.1007/s00005-023-00691-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — The correlation between Motor Unit Potentials (MUP) duration, assessed by EMG in the deltoideus and the biceps brachii, and upper extremity functional test of PUL 2.0 in three DMD patients from baseline up to 12 months after systemic–intraosseous administration of the DT-DEC01 therapy. The correlation analysis between MUP duration and PUL 2.0 test confirmed: A a strong and significant correlation between the increase in MUP duration recorded in the deltoideus muscle and the improved functional outcomes assessed by the PUL test (correlation coefficient r = 0.977, P = 0.023), B a strong correlation between the increase in MUP duration recorded in the biceps brachii muscle and the improved functional outcomes assessed by the PUL test (correlation coefficient r = 0.882; P = 0.118) up to the 12 months after DT-DEC01 therapy administration. The Pearson correlation coefficient was used to assess the correlation. Square points indicate correlation of PUL 2.0 outcomes and MUP duration in (A) deltoideus muscle and in (B) biceps brachii. Linear regression is presented with solid line for (A) deltoideus muscle correlation (Y = 0.2045 × X + 80.10) and for (B) biceps brachii correlation (Y = 0.1379 × X + 87.82) and with 95% confidence interval indicated by dotted line. V0a screening visit, V5 3-month, V6 6-month, V7 12-month visit after DT-DEC01 administration