Fig. 9.

The correlation between motor unit potentials (MUP) duration assessed by EMG in the biceps brachii, and upper extremity functional test of grip strength, measured by dynamometer in three DMD patients from baseline up to 12 months after systemic–intraosseous administration of the DT-DEC01 therapy. The correlation analysis confirmed a strong and significant correlation between the increased MUP duration in the biceps brachii muscle and the improved functional outcomes of upper extremity assessed by grip strength (correlation coefficient r = 0.981, P = 0.019) throughout the 12 months of follow-up period after DT-DEC01 therapy administration. The Pearson correlation coefficient was used to assess the correlation. Square points indicate correlation of grip strength outcomes and MUP duration in biceps brachii. Linear regression is presented with a solid line (Y = 0.2276 × X + 78.40) with 95% confidence interval indicated by dotted line. V0a screening visit, V5 3-month, V6 6-month, V7 12-month visit after DT-DEC01 administration