Table 1.

The summary of average MUP duration assessed by EMG in the selected muscles of the DMD patients at baseline and at 3, 6, and 12 months after systemic–intraosseous administration of DT-DEC01 therapy

Parameter	The average MUP duration* (ms)
	Deltoideus	MUP (n)	Biceps brachii	MUP (n)	Rectus femoris	MUP (n)	Gastrocnemius	MUP (n)
Patient 1
Baseline	3.65 ± 0.21	10	3.96 ± 0.14	10	3.27 ± 0.19	7	4.37 ± 0.25	4
Month 3	4.84 ± 0.29	10	5.83 ± 0.26	10	3.73 ± 0.14	11	3.47 ± 0.29	10
Month 6	4.18 ± 0.12	12	7.08 ± 0.76	10	4.59 ± 0.40	11	5.61 ± 0.58	11
Month 12	4.55 ± 0.30	11	3.86 ± 0.11	11	3.63 ± 0.18	12	6.66 ± 0.17	16
Change from baseline at Month 12	24.5 ± 8.2%	43	−2.5 ± 2.8%	41	11.0 ± 5.4%	41	52.6 ± 4.0%	41
Patient 2
Baseline	2.60 ± 0.23	10	2.12 ± 0.14	10	3.16 ± 0.12	10	5.87 ± 0.27	10
Month 3	5.66 ± 0.46	11	3.86 ± 0.17	11	3.27 ± 0.12	10	4.72 ± 0.16	10
Month 6	4.96 ± 0.40	10	5.15 ± 0.28	11	3.11 ± 0.15	10	7.62 ± 0.28	10
Month 12	3.48 ± 0.24	14	5.29 ± 0.41	12	5.16 ± 0.25	12	7.82 ± 0.45	14
Change from baseline at Month 12	33.6 ± 9.3%	45	149.6 ± 19.3%	44	63.5 ± 7.8%	42	33.2 ± 7.6%	44
Patient 3
Baseline	3.76 ± 0.33	10	3.49 ± 0.36	10	4.06 ± 0.34	10	4.92 ± 0.16	11
Month 3	6.21 ± 0.49	12	4.17 ± 0.30	10	6.33 ± 0.45	12	6.09 ± 0.22	12
Month 6	5.94 ± 0.34	13	5.10 ± 0.18	10	4.83 ± 0.27	12	7.15 ± 0.34	10
Month 12	6.01 ± 0.29	14	4.60 ± 0.19	13	4.52 ± 0.18	13	5.47 ± 0.27	12
Change from baseline at Month 12	59.9 ± 7.6%	49	31.6 ± 5.5%	43	11.3 ± 4.4%	47	11.1 ± 5.5%	45
Average change from baseline at Month 12	40.5 ± 5.4%	Total MUP 137	60.5 ± 12.7%	Total MUP 128	28.1 ± 5.3%	Total MUP 130	33.8 ± 4.2%	Total MUP 130

*The data are presented as mean ± SEM. A grand total of 525 MUPs were assessed