Table 2.
Pre-vedolizumab vitamin D levels and Ulcerative Colitis outcomes.
| Vitamin D < 30 ng/mL (n = 16) |
Vitamin D ≥ 30 ng/mL (n = 18) |
p-Value | |
|---|---|---|---|
| Age (years) | 42.50 [33.25, 56.0] | 39.50 [34.75, 48.0] | 0.534 |
| Male (%) | 8 (50.0) | 5 (27.8) | 0.328 |
| Race (%) | 0.987 | ||
| Asian | 1 (6.2) | 1 (5.6) | |
| Black | 2 (12.5) | 2 (11.1) | |
| Caucasian | 13 (81.2) | 15 (83.3) | |
| Disease Duration (years) | 12.4 [6.2, 15.8] | 9.4 [5.0, 13.1] | 0.293 |
| Vedolizumab Dose Escalation (n (%)) | 10 (62.5) | 14 (77.8) | 0.549 |
| Iron Supplementation | 1 (6.2) | 1 (5.6) | 1.00 |
| Pre-Treatment Scores | |||
| UCAI score | 6.5 [4.0, 9.25] | 6.0 [1.5, 8.0] | 0.641 |
| CRP (mg/dL) | 4.0 [0.5 11.32] | 1.5 [0.9, 5.2] | 0.734 |
| ESR (mm/h) | 11.0 [6.0, 47.0] | 6.0 [2.0, 11.0] | 0.073 |
| Fecal Calprotectin (μg/mg) (median (IQR)) | 299.0 [149.0, 844.0] | 1377.9 [1313.9, 1441.8] | 0.245 |
| Fecal Lactoferrin (μg/g) | 400.2 [400.2, 400.2] | 71.7 [30.0, 130.9] | 0.143 |
| UCEIS Score (median (IQR)) | 7.0 [3.0, 9.0] | 8.0 [4.5, 9.5] | 0.716 |
| BMI | 24.6 [23.6, 29.1] | 24.5 [22.1, 30.6] | 0.72 |
| Vitamin D (ng/mL) | 22.5 [17.5, 26.5] | 38.7 [35.3, 48.6] | <0.001 |
| Albumin (g/dL) | 3.7 [2.7, 3.9] | 3.9 [3.1, 4.0] | 0.533 |
| Iron (umol/L) | 62.0 [22.5, 100.5] | 94.0 [58.0, 110.5] | 0.11 |
| TIBC (μg/dL) | 311.0 [285.0, 361.0] | 335.0 [293.5, 380.5] | 0.42 |
| Ferritin (μg/L) | 38.0 [22.5, 115.5] | 60.0 [29.5, 104.5] | 0.575 |
| Iron Sat (%) | 20.5 [10.3, 28.0] | 27.5 [21.0, 33.0] | 0.164 |
| Vitamin B12 (pg/mL) | 526.5 [357.5, 825.3] | 701.0 [414.3, 898.5] | 0.378 |
| Folate (ng/mL) | 13.4 [10.6, 14.9] | 12.2 [11.2, 18.1] | 0.979 |
| Zinc (μg/dL) (mean [SD]) | 68.7 (12.7) | 82.7 (21.6) | 0.173 |
| # Prior Advanced Therapies (mean (SD)) | 1.00 [0.00, 1.00] | 1.00 [1.00, 2.00] | 0.199 |
| Post-Treatment Scores | |||
| UCAI core | 0.5 [0.0, 3.3] | 1.0 [0.0, 1.3] | 0.838 |
| CRP (mg/dL) | 2.8 [1.1, 8.1] | 2.1 [1.0, 4.6] | 0.651 |
| ESR (mm/h) | 11.0 [5.8, 19.0] | 6.0 [2.0, 11.0] | 0.103 |
| Fecal Calprotectin (μg/mg) | 1026.0 [41.8, 2527.5] | 1670.8 [1050.4, 2291.2] | 0.643 |
| Fecal Lactoferrin (μg/g) | 37.0 [21.7, 58.8] | 69.8 [50.2, 96.3] | 0.564 |
| UCEIS score (mean (SD)) | 3.87 (3.7) | 1.5 (2.5) | 0.037 |
| Vedolizumab Level (μg/mL) | 19.9 [11.4, 28.9] | 25.4 [14.1, 34.5] | 0.27 |
| Vedolizumab Replacement Medication | 0.459 | ||
| Infliximab | 1 (33.3) | 2 (50.0) | |
| Ustekinumab | 1 (33.3) | 2 (50.0) | |
| Tofacitinib | 1 (33.3) | 0 (0.0) | |
| BMI | 25.8 [24.3, 29.5] | 24.8 [22.1, 28.8] | 0.541 |
| Vitamin D (ng/mL) | 31.0 [24.5, 49.5] | 56.0 [46.0, 66.0] | 0.007 |
| Albumin (g/dL) | 3.8 [3.3, 4.0] | 3.9 [3.7, 4.2] | 0.338 |
| Iron (umol/L) | 79.5 [53.5, 87.0] | 89.5 [54.3, 110.8] | 0.351 |
| TIBC (μg/dL) | 328.0 [294.3, 360.3] | 326.5 [299.3, 346.0] | 1 |
| Ferritin (μg/L) | 54.0 [25.3, 122.5] | 50.0 [25.0, 126.0] | 0.885 |
| Iron Sat (%) | 24.50 [17.50, 33.00] | 27.5 [17.3, 37.8] | 0.809 |
| Vitamin B12 (pg/mL) | 556.0 [462.0, 606.5] | 548.0 [469.0, 1093.0] | 0.571 |
| Folate (ng/mL) | 12.6 [10.4, 18.5] | 10.5 [7.5, 20.0] | 0.321 |
| Zinc (μg/dL) (mean (SD)) | 83.53 (9.99) | 73.00 (5.66) | 0.253 |
Data shown in n (%) or median (IQR (interquartile range) unless otherwise stated.