Table 3.
Pre-vedolizumab vitamin D levels (<30 ng/mL) and Crohn’s Disease outcomes.
| Vitamin D < 30 ng/mL (n = 19) |
Vitamin D ≥ 30 ng/mL (n = 12) |
p-Value | |
|---|---|---|---|
| Age (years) | 41.0 [30.5, 57.5] | 43.5 [31.8, 62.0] | 0.776 |
| Male (%) | 5 (26.3) | 2 (16.7) | 0.853 |
| Race (%) | 0.111 | ||
| Asian | 0 (0.0) | 2 (16.7) | |
| Black | 5 (26.3) | 1 (8.3) | |
| Caucasian | 14 (73.7) | 9 (75.0) | |
| Disease Duration (years) | 14.2 [4.5, 20.6] | 14.4 [8.2, 25.4] | 0.273 |
| Disease Location (%) | 0.339 | ||
| 1 Colon Only | 8 (42.1) | 3 (25.0) | |
| 2 Proximal (Gastric ± Small bowel) | 5 (26.3) | 2 (16.7) | |
| 3 Proximal and Colon | 6 (31.6) | 7 (58.3) | |
| Vedolizumab Dose Escalation (%) | 8 (42.1) | 8 (66.7) | 0.335 |
| Iron Supplementation | 0 (0) | 1 (8.3) | 0.814 |
| Pre-Treatment Scores | |||
| HBI score | 6.0 [3.0, 11.5] | 5.0 [3.0, 10.0] | 0.725 |
| CRP (mg/dL) | 8.2 [2.0, 21.8] | 2.6 [0.6, 12.1] | 0.212 |
| ESR (mm/h) | 25.0 [13.0, 50.0] | 16.0 [5.0, 31.0] | 0.403 |
| Fecal Calprotectin (μg/mg) | N/A | 272.5 [171.7, 373.2] | N/A |
| Fecal Lactoferrin (μg/g) | 252.5 [252.5, 252.5] | 52.5 [29.3, 75.7] | 0.221 |
| SES-CD score | 17.0 [13.5, 22.0] | 13.0 [11.5, 17.8] | 0.721 |
| # Prior Surgeries | 1.0 [1.0, 1.0] | 2.0 [1.0, 2.0] | 0.129 |
| BMI (kg/m2) | 24.1 [19.3, 30.4] | 22.4 [21.5, 24.2] | 0.525 |
| Vitamin D ( ng/mL) | 17.4 [14.7, 22.0] | 40.0 [33.8, 49.8] | <0.001 |
| Albumin (g/dL) | 3.0 [2.5, 4.0] | 3.6 [3.3, 4.1] | 0.451 |
| Iron (umol/L) | 35.5 [25.0, 57.8] | 81.0 [26.0, 90.5] | 0.132 |
| TIBC (μg/dL) | 301.0 [266.5, 383.5] | 323.0 [247.0, 327.0] | 0.586 |
| Ferritin (μg/L) | 58.0 [14.0, 141.0] | 82.0 [60.0, 122.0] | 0.35 |
| Iron Sat (%) | 12.0 [6.25, 17.25] | 25.0 [17.5, 28.5] | 0.008 |
| Vitamin B12 (pg/mL) | 433.5 [378.5, 551.0] | 885.0 [645.5, 1285.3] | 0.003 |
| Folate (ng/mL) | 9.6 [6.8, 13.7] | 18.6 [10.2, 20.7] | 0.054 |
| Zinc (μg/dL) (mean (SD)) | 66.9 (20.0) | 73.8 (17.6) | 0.521 |
| Prior Biologics | 1.00 [1.00, 2.00] | 2.00 [1.00, 3.00] | 0.13 |
| Post-Treatment Scores | |||
| HBI score | 1.0 [0.0, 5.0] | 5.5 [1.0, 10.0] | 0.163 |
| CRP (mg/dL) | 1.6 [0.4, 4.3] | 3.0 [1.5, 18.7] | 0.101 |
| ESR (mm/h) | 7.5 [2.0, 21.3] | 9.0 [2.0, 11.0] | 0.692 |
| Fecal Calprotectin (μg/mg) | 24.0 [12.3, 702.0] | 2.5 [2.5, 156.7] | 0.825 |
| Fecal Lactoferrin (μg/g) | 194.0 [29.3, 737.3] | 30.0 [30.0, 58.6] | 0.793 |
| SES-CD Score (mean (SD)) | 3.6 (3.8) | 6.3 (12.9) | 0.539 |
| Vedolizumab level (μg/mL) | 14.4 [11.1, 23.0] | 27.4 [22.4, 42.7] | 0.045 |
| Vedo Replacement Drug | 0.189 | ||
| Infliximab | 1 (33.3) | 2 (66.7) | |
| Ustekinumab | 2 (66.7) | 0 (0.0) | |
| Tofacitinib | 0 (0.0) | 1 (33.3) | |
| BMI (kg/m2) | 24.7 [21.6, 33.5] | 24.4 [22.3, 26.5] | 0.446 |
| Vitamin D (ng/mL) | 27.0 [22.0, 50.5] | 31.0 [29.5, 64.4] | 0.081 |
| Albumin (g/dL) | 3.5 [2.7, 3.9] | 3.5 [3.3, 4.1] | 0.602 |
| Iron (umol/L) | 65.0 [54.0, 86.0] | 96.5 [77.0, 116.3] | 0.025 |
| TIBC (μg/dL) | 305.0 [278.0, 374.0] | 266.5 [255.5, 338.0] | 0.335 |
| Ferritin (μg/L) | 83.0 [52.5, 300.0] | 144.0 [61.5, 256.0] | 0.621 |
| Iron Sat (%) | 24.0 [17.0, 30.0] | 35.5 [33.5, 40.8] | 0.007 |
| Vitamin B12 (pg/mL) | 572.0 [445.5, 718.5] | 598.0 [473.0, 1243.0] | 0.445 |
| Folate (ng/mL) | 10.7 [9.6, 19.2] | 17.1 [10.4, 19.3] | 0.631 |
| Zinc (μg/dL) (mean (SD)) | 71.13 (10.59) | 77.40 (13.56) | 0.411 |
Data shown in n (%) or median (IQR) unless otherwise stated. Statistically significant results are bolded.