Figure 3.

Cotton rat challenge study to assess vaccine efficacy against RSV infection. (A,B): experimental design. Protection after RSV challenge as assessed via lung viral load (C) and nose viral load (D) measured in pfu/g of tissue (limit of detection 2.0 Log10 pfu/g). (E) Neutralising antibody (nAb) responses as assessed via RSV 60% plaque-reduction neutralising test (PRNT₆₀) against live RSV strain A2 (lower limit of detection 4.32 Log2 and upper limit of detection 11.32 Log2). (F) Humoral immune responses as assessed via RSV-F ELISA (OD450). Horizontal lines represent mean values per group (C–F).