. 2023 Nov 7;16(11):1573. doi: 10.3390/ph16111573

Table 8.

Cytotoxicity data reported in the literature for Turnera spp.

Method	Ref.	Species	Part of the Plant	Extract/Compound	Cell Line	CC₅₀ (µg/mL)
MTT	[118]	T. diffusa	-	EO	B16F10	83.9 *
					B16F10	161.3 **
					HEK293	143.2 **
					HEK293	152.5 *
					HELA	109.5 **
					HepG2	186.5 *
					HepG2	199.3 **
					MCF7	139.9 **
					Vero	90.5 *
					Vero	135 **
	[94]	T. diffusa	A, R	EO	Vero	52.2
	[50]	T. diffusa	H	AQ	SH-SY5Y	>500
	[119]	T. diffusa	H, T	M	C-33 A	45.1
					Fibroblasts	63.24
					HepG2	43.87
					MDA-MB-231	30.67
					SiHa	50.14
					T-47D	54.02
	[120]	T. diffusa	H, T	EO	THP-1	>100
	[120]	T. diffusa	H, T	EO	Vero	88.1
	[14]	T. subulata	CL	E	MCF 7	>300
	[14]	T. subulata	CL	M	MCF 7	>300
	[87]	T. subulata	H	HA	3T3	>1000
				HA	HEK293	>1000
				Fr. AE	3T3	>1000
				Fr. AE	HEK293	>1000
	[20]	T. subulata	H	HA	HaCat	100
	[20]	T. subulata	H	HA	HDF	100
	[25]	T. ulmifolia	T, H, F	HA	HFF1	>1000
MTT and Alamar blue	[36]	T. subulata	F	AQ	RAW 264.7	>500
			F	HA	RAW 264.7	>500
			H	AQ	RAW 264.7	>500
			H	HA	RAW 264.7	>500
Neutral red uptake	[96]	T. subulata	A	AE	Vero	245.4
				AQ	Vero	nd
				CH	Vero	281.4
				E	Vero	nd
				HX	Vero	471.3
				M	Vero	nd
Total macromolecular content	[62]	T. ulmifolia	-	Fr. E	V79	465,000

Ref.: reference. CL: callus. H: leaf. T: stem. F: flower. A: aerial. R: root. AQ: aqueous. HA: hydroalcoholic. AE: ethyl acetate. E: ethanol. HX: hexane. CH: chloroform. M: methanol. EO: essential oil. nd: no significant toxicity above 640 µg/mL. CC: cytotoxic concentration. (-): not reported. *: treated after cell proliferation. **: treated prior to cell proliferation.