Table 5.
Characterization of different RS-loaded glycethosomal in situ gel formulations.
| Formulation | Gel Base | Mucoadhesive Agent | Gel/Glycethosome Ratio (w/w) | pH | Viscosity (cP) |
Spreadability (cm) | Mucoadhesive Strength (dyne/cm2) |
|---|---|---|---|---|---|---|---|
| G2 | P407 (20% w/w) |
Carbopol 940 (0.2% w/w) | 4:1 | 6.41 ± 0.04 | 15,366.67 ± 169.97 | 3.00 ± 0.08 | 4799.04 ± 63.71 |
| G5 | P407 (20% w/w) |
HPMC-K4M (1% w/w) |
4:1 | 6.58 ± 0.12 | 11,133.33 ± 47.14 | 3.26 ± 0.05 | 4163.23 ± 38.97 |
| G9 | P407 (20% w/w) |
PVP K30 (1% w/w) |
5:1 | 6.74 ± 0.02 | 16,366.67 ± 309.12 | 2.53 ± 0.12 | 5197.24 ± 53.05 |
P407, poloxamer 407; HPMC-K4M, hydroxypropyl methyl cellulose-K4M; PVP K30, polyvinylpyrrolidone K30.