Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2005 Mar 18;33(5):1628–1636. doi: 10.1093/nar/gki303

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author 2005. Published by Oxford University Press. All rights reserved

The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oupjournals.org

PMC Copyright notice

Microsatellite changes in Msh2^−/− mouse embryonic fibroblast (MEF) cells and in tumours that arose in Msh2-knockout mice. (A) More than 20 subclones were isolated from RH95021 (Msh2^−/−) MEF cells and microsatellite changes were compared among these subclones. The majority exhibited the same configuration (clone a) and a few deviated from this predominant pattern (clone b–d). In each clone, the pattern of clone A has been superimposed with green lines, to facilitate comparison. Results obtained in D6Mit59 microsatellite are shown. (B) RH95021 cells were continuously cultured and sampled at different passages. Results obtained in D6Mit59 microsatellite at passage 1, 20, 30 and 81 are shown. In passage 81, the initial profile at passage 1 has been superimposed with a green line. (C) Tumours that arose in vivo in Msh2-knockout mice were analysed. Representative results obtained in D7Mit91 (tumours a and b) and D6Mit59 (tumours c and d) microsatellites are shown: red lines, tumour; green lines, the corresponding normal tissue.