Table 2.

p53 mutations found in 79 colorectal carcinomas

No.	Patient	EX05	EX06	EX07	EX08	EX09	Codon change	Base substitution	(type)	AA change	MSI
1	IC628				273		CGT → CAT	G:C → A:T	TS	Arg → His	N
2	IC630		196				CGA → TGA	G:C → A:T	TS	Arg → stop	A
3	IC634				306		CGA → TGA	G:C → A:T	TS	Arg → stop	N
4	IC668		193				CAT → CGT	A:T → G:C	TS	His → Arg	N
5	IC669	175					CGC → CAC	G:C → A:T	TS	Arg → His	A
6	IC673	176					TGC → AGC	A:T → T:A	TV	Cys → Ser	N
7	IC674				285		GAG → AAG	G:C → A:T	TS	Glu → Lys	N
8	IC680		ND	255			ATC → ACC	A:T → G:C	TS	Ile → Thr	A
9	IC693	179					CAT → CTT	A:T → T:A	TV	His → Leu	A
10	IC694				273		CGT → CAT	G:C → A:T	TS	Arg → His	A
11	IC711			239			AAC → GAC	A:T → G:C	TS	Asn → Asp	N
12	IC721	175					CGC → CAC	G:C → A:T	TS	Arg → His	A
13	IC748		190			ND	CCT → CTT	G:C → A:T	TS	Pro → Leu	A
14	IC754		196				CGA → CCA	G:C → C:G	TV	Arg → Pro	N
15	IC763	151					CCC → CAC	G:C → T:A	TV	Pro → His	N
16	IC772	175					CGC → CAC	G:C → A:T	TS	Arg → His	A
17	IC778	175	ND				CGC → CAC	G:C → A:T	TS	Arg → His	N
18	IC784		214		ND	ND	CAT → CGT	A:T → G:C	TS	His → Arg	A
19	IC808		205				TAT → GAT	A:T → C:G	TV	Tyr → Asp	A
20	IC812		190				CCT → CTT	G:C → A:T	TS	Pro → Leu	N
21	IC816				273		CGT → CAT	G:C → A:T	TS	Arg → His	A
22	IC819			248			CGG → CAG	G:C → A:T	TS	Arg → Gln	N
23	IC860				273		CGT → CAT	G:C → A:T	TS	Arg → His	A

MSI, microsatellite instability; N, negative; A, Type A MSI; TS, transition; TV, transversion; ND, not determined. Bold codon numbers indicate the acknowledged hot-spots for mutation.