Table 4.
Predicted and observed pharmacokinetic parameters of tacrolimus after oral administration in heart transplant patients.
| Dose | AUC0–12h | Cmax | Reference | ||||
|---|---|---|---|---|---|---|---|
| Mean ± SD Pred (ng × h/mL) |
Obs (ng × h/mL) | FE | Mean ± SD Pred (ng/mL) |
Obs (ng/mL) | FE | ||
| 1.0 mg | 50.6 ± 18.7 | 70.6 | 0.72 | 7.3 ± 3.6 | 10.7 | 0.68 | [41] |
| 2.0 mg | 101.3 ± 27.5 | 116.7 | 0.87 | 14.6 ± 4.9 | 16.3 | 0.90 | [40] |
| 3.0 mg | 151.9 ± 33.1 | 167.2 | 0.91 | 21.9 ± 2.5 | 18.0 | 1.22 | [40] |
| 3.5 mg | 177.3 ± 39.6 | 152.6 | 1.16 | 25.6 ± 4.7 | 24.7 | 1.04 | [40] |
| 4.5 mg | 227.9 ± 54.2 | 230.0 | 0.99 | 32.9 ± 5.3 | 34.7 | 0.95 | [40] |
SD: standard deviation; AUC0–12h: area under the concentration–time curve from 0 to 12 h; Cmax: peak blood concentration; Pred: predicted value; Obs: observed value; FE: fold error.