Table 5.
Sensitivity analysis for AUC0-last, Cmax, and Ctrough of tacrolimus.
| Input Parameter | Sensitivity Value for AUC0-last | Sensitivity Value for Cmax | Sensitivity Value for Ctrough |
|---|---|---|---|
| Fraction unbound in plasma | −1.15 | −0.66 | −1.66 |
| Hematocrit | 0.91 | 0.67 | 1.06 |
| Intrinsic clearance (L/h) | −0.74 | −0.47 | −1.09 |
| Fraction of activity of CYP3A5 | −0.30 | −0.17 | −0.45 |
| Fraction of activity of CYP3A4 | −0.15 | −0.09 | −0.22 |
| Bodyweight (kg) | −0.04 | −0.4 | −0.13 |
| Proportion of adipose tissue | 0.02 | 0.17 | 0.05 |
AUC0-last: the area under the curve during a dosing interval; Cmax, peak blood concentration; Ctrough, trough concentration. Sensitivity values less than 0.1 were not listed.