. 2023 Nov 3;15(11):2580. doi: 10.3390/pharmaceutics15112580

Table 6.

Predicted pharmacokinetic parameters of tacrolimus after oral administration in heart transplant patients.

Dose Regimen	Population	AUC_0–24	C_max	C_trough
Dose Regimen	Population	Pred (ng × h/mL)	Pred (ng/mL)	Pred (ng/mL)
Tacrolimus, 2.5 mg, single dose	EM	119.29 ± 34.00	14.27 ± 3.44	-
Tacrolimus, 2.5 mg, single dose	PM	191.91 ± 40.74	20.32 ± 3.55	-
Tacrolimus, 2.5 mg, q12h	EM	-	23.08 ± 3.86	9.62 ± 2.47
Tacrolimus, 2.5 mg, q12h	PM	-	40.37 ± 5.13	21.00 ± 3.24

Data are shown as the mean ± SD; AUC_0–24: area under the concentration–time curve from 0 to 24 h; C_max: peak blood concentration; C_trough: steady-state trough concentration; Pred: predicted value; EM: extensive metabolizers (CYP3A5*1*1 or *1*3 and CYP3A4*18B*18B or CYP3A4*1*18B); PM: poor metabolizers (CYP3A5*3*3 and CYP3A4*1*1).