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Spray-dried dispersion of PVA 3-82 with ritonavir vs. marketed formulation. (a) X-ray powder diffraction at reflector mode 3°–50° 2θ (deg), scan speed 10° 2θ (deg)min, step size 0.02θ (deg). Acceleration voltage 45 kV and 15 mA current. (b) An amount of 100 mg of RIT (calculated from DL) is added to 500 mL of FaSSIF, Apparatus 2, paddle, 75 rpm at 37 °C, UV Vis determination at 215 nm.
