Table 1.

APIs used in this work and their chemico-physical properties [7,8,9,10,11].

API	Chemical Structure [12,13,14]	BSC	pKa	Solubility at pH 1.2	Solubility at pH 6.8
Indomethacin		II	4.5	0.0115 mg/mL	0.2843 mg/mL
Ketoconazole		II	2.9 6.5	20.33 mg/mL	0.007 mg/mL
Ritonavir		IV	1.8 2.6	0.400 mg/mL	0.001 mg/mL