TABLE 1.
Toxicity trial | Time period | Dose every: | Dose increment(s), mg kg−1 | Accumulated dose, mg kg−1 |
---|---|---|---|---|
I | 0–10 h | 2 h | 1 × 0.045, 5 × 0.03 | 0.195 |
20–22 h | 2 h | 2 × 0.03 | 0.255 | |
45–57 h | 6 h | 2 × 0.015, 1 × 0.012 | 0.297 | |
140–152 h | 1 h | 13 × 0.015 | 0.492 | |
II | 0–12 h | 2 h | 6 × 0.03, 1 × 0.015 | 0.195 |
22–24 h | 2 h | 2 × 0.03 | 0.255 | |
38–42 h | 2 h | 3 × 0.015 | 0.300 | |
46 h | NA | 1 × 0.03 | 0.330 |
NA, not applicable.