Table 4.
Predicted anti-RBD adjusted means (log2 scale) from fitting a linear mixed model.
| Anti-RBD (log2) Adjusted * Means | T1 95% CI |
T2 95% CI |
T3 95% CI |
T4 95% CI |
T5 95% CI |
T6 95% CI |
p-Value § |
|---|---|---|---|---|---|---|---|
| CD4 at T1 | <0.001 | ||||||
| LCD4 | −4.7 (−5.5, −3.9) | 1.1 (0.3, 1.9) | 5.0 (4.2, 5.8) | 2.5 (1.6, 3.3) | 8.0 (7.1, 8.9) | 5.6 (4.2, 7.0) | |
| ICD4 | −5.2 (−5.7, −4.7) | 3.2 (2.7, 3.7) | 9.1 (8.5, 9.6) | 7.0 (6.5, 7.5) | 8.1 (7.3, 9.0) | 4.4 (3.9, 5.0) | |
| HCD4 | −4.8 (−5.2, −4.4) | 4.4 (4.0, 4.8) | 9.1 (8.6, 9.6) | 7.4 (7.1, 7.8) | 7.7 (6.8, 8.6) | 4.8 (4.3, 5.2) | |
| CD4/CD8 ratio at T1 | 0.009 | ||||||
| LR | −4.9 (−5.3, −4.4) | 2.8 (2.4, 3.3) | 6.6 (6.2, 7.0) | 3.8 (3.3, 4.2) | 8.7 (8.2, 9.2) | 7.3 (6.5, 8.0) | |
| IR | −5.0 (−5.6, −4.4) | 4.0 (3.4, 4.5) | 9.2 (8.5, 9.8) | 7.2 (6.7, 7.7) | 8.0 (6.8, 9.3) | 4.7 (4.1, 5.3) | |
| HR | −4.8 (−5.4, −4.3) | 4.4 (3.9, 5.0) | 9.3 (8.6, 10.0) | 7.4 (6.9, 7.9) | 7.7 (6.4, 9.0) | 5.1 (4.5, 5.8) |
§ F-test p-value for type 3 interaction; * Model adjusted for age, VL ≤ 50 cps/mL at 1st vaccination, no. of comorbidities and nadir CD4 count. time points: T1: before vaccination; T2: at the time of 2nd dose; T3: 1 month after 2nd dose; T4: at the time of the 3rd dose; T5: 1 month after the 3rd dose; T6: 6 months after the 3rd dose.