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. 2023 Oct 28;11(11):1655. doi: 10.3390/vaccines11111655

Figure 4.

Figure 4

Broadly neutralizing antibodies induced by spike nanodiscs. (A) Schematic representation of immunization scheme and immunogens used. CD-1 mice (n = 5 per group) were immunized as indicated. (B) Anti-spike ELISA IgG titer using WT, BA.1, or BA.2 as coating antigen (C) WT, BA.1, or BA.2 spike/ACE-2 interaction inhibition by immunized mice sera after 1:20 dilution. (D) Pseudo-typed virus neutralization assay using WT, BA.1, or BA.2 decorated pseudo-typed virus. For (B,D), log10-transformed titer was analyzed by one-way ANOVA test, followed by Tukey’s comparisons. For (C), data were analyzed by one-way ANOVA test, followed by Tukey’s comparisons. * p < 0.05, ** p < 0.01 and **** p < 0.001 against WT control; $ p < 0.05, $$ p < 0.01, $$$ p < 0.005, and $$$$ p < 0.001 against BA.1 Control; # p < 0.05, ### p < 0.005, and #### p < 0.001 against BA.2 Control.