Table 2.
Comparison of the physicochemical characteristics of four different PEGs incorporated into the core of the SLN matrix with two different protocols.
| PEG (150 mg) 1 | PSD (nm) 2 | PdI | ZP (mV) | PSD (nm) | PdI | ZP (mV) |
|---|---|---|---|---|---|---|
| Original Protocol | Modified Protocol | |||||
| Brij S100 | 243.3 | 0.118 | 23.7 | 190.90 | 0.10 | 25.10 |
| DSPE | — | — | — | 171.5 | 0.131 | 27.5 |
| Gelucire | 222.8 | 0.176 | 34.5 | 171.20 | 0.16 | 27.40 |
| Myrj 52 | 223.7 | 0.129 | 32.3 | 183.10 | 0.19 | 31.40 |
| Myrj S100 | 227.6 | 0.114 | 29.8 | 180.10 | 0.14 | 27.40 |
| CO | 237.4 | 0.163 | 34.8 | 202.10 | 0.17 | 37.40 |
1 DSPE-mPEG2000 is the most expensive PEG excipient (1 g = $500) used in this study. It was only used in the final essays. CO represents 300 mg of cholesteryl oleate, corresponding to the formulation without PEG. 2 Particle size distribution (PSD), polydispersity index (PdI), and zeta potential (ZP) of all the formulations manufactured.