Skip to main content
. 2023 Nov 2;16(11):1554. doi: 10.3390/ph16111554

Figure 3.

Figure 3

Illustrative brain presentation, ex vivo and in vivo (a,B,c,D,e,F,g,H,i,J,k,L), in control rats (small italic letters) (a,c,e,g,i,k) and BPC 157-treated rats (capital italic letters) (B,D,F,H,J,L). Considerable gross brain failure (swelling) or recovery (counteracted swelling) was noted after decompression and reperfusion in rats who were subjected to the intra-abdominal hypertension of 25 mmHg for 60 min (a,B,c,D) (i), 30 mmHg for 30 min (e,F,g,H) (ii), or 40 mmHg for 30 min (iii) (i,J,k,L) and sacrificed after the corresponding reperfusion period (60 min (i) (a,B,c,D) or 30 min (ii (e,F,g,H); iii (i,J,k,L))) depending on whether they had received (sc) saline (controls) or BPC 157 at 3 min reperfusion times. Commonly, controls presented marked brain swelling. Contrarily, BPC 157-treated rats exhibited a consistent therapy effect and counteracted brain swelling.