Table 1.
Blood pressures and thrombosis in rats at 60 min, 30 min, and 30 min following decompression after compression with intra-abdominal hypertension (25 mmHg/60 min; 30 mmHg/30 min; 40 mmHg/30 min). * p ˂ 0.05, at least vs. control.
| Blood Pressures and Thrombosis in Rats at 60 min, 30 min, and 25 min Following Decompression after Compression with Intra-abdominal Hypertension (25 mmHg/60 min; 30 mmHg/30 min; 40 mmHg/25 min) | |||
|---|---|---|---|
| 60 min (25 mmHg) | 30 min (30 mmHg) | 30 min (40 mmHg) | |
| Superior sagittal sinus pressure, mm Hg, means ± SD | |||
| Control | 7 ± 1 | 8 ± 1 | 7 ± 1 |
| BPC 157 10 μg/kg | −2 ± 1 * | −1 ± 1 * | −1 ± 1 * |
| BPC 157 10 ng/kg | −1 ± 1 * | −1 ± 1 * | −2 ± 1 * |
| Portal pressure, mm Hg, means ± SD | |||
| Control | 17 ± 1 | 17 ± 2 | 18 ± 3 |
| BPC 157 10 μg/kg | 6 ± 1 * | 5 ± 1 * | 6 ± 1 * |
| BPC 157 10 ng/kg | 6 ± 1 * | 5 ± 1 * | 6 ± 1 * |
| Caval pressure, mm Hg, means ± SD | |||
| Control | 10 ± 2 | 11 ± 1 | 12 ± 2 |
| BPC 157 10 μg/kg | 5 ± 1 * | 5 ± 1 * | 5 ± 1 * |
| BPC 157 10 ng/kg | 5 ± 1 * | 5 ± 1 * | 6 ± 1 * |
| Abdominal aorta pressure, mm Hg, means ± SD | |||
| Control | 70 ± 5 | 65 ± 5 | 70 ± 5 |
| BPC 157 10 μg/kg | 100 ± 5 * | 105 ± 7 * | 98 ± 6 * |
| BPC 157 10 ng/kg | 102 ± 7 * | 98 ± 8 * | 100 ± 7 * |
| Superior sagittal sinus, thrombus mass, g, means ± SD | |||
| Control | 0.0019 ± 0.0004 | 0.0021 ± 0.0006 | 0.0042 ± 0.0008 |
| BPC 157 10 μg/kg | 0.0002 ± 0.0001 * | 0.0006 ± 0.0002 * | 0.0003 ± 0.0001 * |
| BPC 157 10 ng/kg | 0.0001 ± 0.0001 * | 0.0007 ± 0.0001 * | 0.0005 ± 0.0002 * |
| Portal vein, thrombus mass, g, means ± SD | |||
| Control | 0.0022 ± 0.0004 | 0.0035 ± 0.0006 | 0.0058 ± 0.0007 |
| BPC 157 10 μg/kg | 0.0005 ± 0.0001 * | 0.0013 ± 0.0003 * | 0.0002 ± 0.0001 * |
| BPC 157 10 ng/kg | 0.0004 ± 0.0001 * | 0.0010 ± 0.0002 * | 0.0004 ± 0.0001 * |
| Inferior caval vein, thrombus mass, g, means ± SD | |||
| Control | 0.0031 ± 0.0004 | 0.0082 ± 0.0004 | 0.0223 ± 0.0014 |
| BPC 157 10 μg/kg | 0.0008 ± 0.0004 * | 0.0015 ± 0.0003 * | 0.0029 ± 0.0005 * |
| BPC 157 10 ng/kg | 0.0006 ± 0.0002 * | 0.0010 ± 0.0004 * | 0.0010 ± 0.0004 * |
| Abdominal aorta, thrombus mass, g, means ± SD | |||
| Control | 0.0019 ± 0.0004 | 0.0022 ± 0.0005 | 0.0061 ± 0.0010 |
| BPC 157 10 μg/kg | 0.0005 ± 0.0001 * | 0.0012 ± 0.0003 * | 0.0011 ± 0.0004 * |
| BPC 157 10 ng/kg | 0.0004 ± 0.0001 * | 0.0010 ± 0.0004 * | 0.0009 ± 0.0002 * |