Table 5.
Lesions, scored microscopically (heart, lung, liver, kidney, stomach, small and large intestine), or macroscopically (stomach), in rats at 60 min, 30 min, and 30 min following decompression after compression with intra-abdominal hypertension (25 mmHg/60 min; 30 mmHg/30 min; 40 mmHg/30 min). * p ˂ 0.05, at least vs. control.
| Lesions, Scored Microscopically (Heart, Lung, Liver, Kidney, Stomach, Small and Large Intestine), or Macroscopically (Stomach), in Rats at 60 min, 30 min, and 30 min Following Decompression after Compression with Intra-Abdominal Hypertension (25 mmHg/60 min; 30 mmHg/30 min; 40 mmHg/30 min) | |||
|---|---|---|---|
| 60 min (25 mmHg) | 30 min (30 mmHg) | 30 min (40 mmHg) | |
| Heart (scored 0–3, Min/Med/Max) | |||
| Control | 3/3/3 | 3/3/3 | 3/3/3 |
| BPC 157 10 μg/kg | 0/0/0 * | 0/0/0 * | 0/0/0 * |
| BPC 157 10 ng/kg | 0/0/0 * | 0/1/1 * | 0/1/1 * |
| Lung (scored 0–3, Min/Med/Max) | |||
| Control | 3/3/3 | 3/3/3 | 3/3/3 |
| BPC 157 10 μg/kg | 0/0/0 * | 0/0/0 * | 0/0/0 * |
| BPC 157 10 ng/kg | 0/0/0 * | 0/0/0 * | 0/0/0 * |
| Liver (scored 0–3, Min/Med/Max) | |||
| Control | 3/3/3 | 3/3/3 | 3/3/3 |
| BPC 157 10 μg/kg | 0/0/0 * | 0/1/1 * | 0/1/1 * |
| BPC 157 10 ng/kg | 0/0/0 * | 0/1/1 * | 0/1/1 * |
| Kidney (scored 0–3, Min/Med/Max) | |||
| Control | 3/3/3 | 3/3/3 | 3/3/3 |
| BPC 157 10 μg/kg | 0/0/0 * | 0/1/1 * | 0/1/1 * |
| BPC 157 10 ng/kg | 0/0/0 * | 0/1/1 * | 0/1/1 * |
| Stomach (sum of longest diameters, mm, means ± SD) | |||
| Control | 3/3/3 | 3/3/3 | 3/3/3 |
| BPC 157 10 μg/kg | 0/0/0 * | 0/0/0 * | 0/0/0 * |
| BPC 157 10 ng/kg | 0/0/0 * | 0/0/0 * | 0/0/0 * |
| Stomach (scored 0–15, Min/Med/Max) | |||
| Control | 3/3/3 | 3/3/3 | 3/3/3 |
| BPC 157 10 μg/kg | 0/0/0 * | 0/0/0 * | 0/0/0 * |
| BPC 157 10 ng/kg | 0/0/0 * | 0/0/0 * | 0/0/0 * |
| Small intestine (scored 0–15, Min/Med/Max) | |||
| Control | 3/3/3 | 3/3/3 | 3/3/3 |
| BPC 157 10 μg/kg | 0/0/0 * | 0/0/0 * | 0/0/0 * |
| BPC 157 10 ng/kg | 0/0/0 * | 0/0/0 * | 0/0/0 * |