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. 2023 Nov 20;15(22):4845. doi: 10.3390/nu15224845

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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ACSL4 and other ferroptosis-relative proteins were regulated by VD/VDR. (A,E) The level of Iron in UC models was higher than in VD pretreatment groups. (B,F) The GSH level was increased in DSS + VD and LPS + VD groups, compared with DSS and LPS groups. (C,G) The expression of relative ferroptosis proteins is shown in vivo and in vitro. (D) The results of RT-PCR showed the change in ACSL4 and GPX4 in cells. Pretreated with VD, the level of ACSL4 slightly declined, and GPX4 improved in LPS + VD group compared with LPS group. Values shown are means ± SD. * p < 0.05, ** p < 0.01, *** p < 0.001 and **** p < 0.0001, n.s., not significant.(n = 3 in each group).