Table 3.
The association between BMI trajectories in late-middle age and risk of dementia in older age
| Trajectory | Model1 | Model2 | Model3 | Model 4 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No.participants | No.event | RR (95% CI) | P value | No.participants | No.event | ARR (95% CI) | P value | No.participants | No.event | ARR (95% CI) | P value | No.participants | No.event | ARR (95% CI) | P value | |
| Ascend BMI with low variation | 3932 | 264 | Reference | 3920 | 262 | Reference | 3902 | 258 | Reference | 3902 | 258 | Reference | ||||
| Decline BMI with low variation | 2690 | 226 | 1.25 (1.05–1.49) | 0.013 | 2681 | 224 | 1.13 (0.95–1.36) | 0.17 | 2674 | 223 | 1.16 (0.97–1.39) | 0.113 | 2674 | 223 | 1.18 (0.98–1.42) | 0.076 |
| Ascend BMI with high variation | 2761 | 225 | 1.21 (1.02–1.45) | 0.033 | 2752 | 224 | 1.28 (1.07–1.54) | 0.007 | 2741 | 224 | 1.27 (1.06–1.53) | 0.01 | 2741 | 224 | 1.27 (1.06–1.52) | 0.011 |
| Decline BMI with high variation | 1464 | 185 | 1.88 (1.56–2.27) | < 0.001 | 1460 | 185 | 1.79 (1.48–2.16) | < 0.001 | 1451 | 184 | 1.75 (1.45–2.12) | < 0.001 | 1451 | 184 | 1.76 (1.45–2.13) | < 0.001 |
BMI Body mass index
Model 1 was a univariate model for the BMI trajectory
Model 2 was additionally adjusted for sex, education, ethnicity, year of aged 65, and marital status
Model 3 was additionally adjusted for smoking status, alcohol consumption, and longstanding illness status. Model 4 was additionally adjusted for the mean BMI group